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Regulation of CED-3 caspase localization and activation by C. elegans nuclear membrane protein NPP-14
Caspases are cysteine proteases with critical roles in apoptosis. The Caenorhabditis elegans caspase CED-3 is activated by autocatalytic cleavage, a process enhanced by CED-4. Here we report that CED-3 zymogen localizes to the perinuclear region in C. elegans germ cells and that CED-3 autocatalytic...
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| Izdano u: | Nat Struct Mol Biol |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5484413/ https://ncbi.nlm.nih.gov/pubmed/27723735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3308 |
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