Limitations of the hCMEC/D3 cell line as a model for Aβ clearance by the human blood‐brain barrier

Alzheimer's disease and cerebral amyloid angiopathy are characterized by accumulation of amyloid‐β (Aβ) at the cerebrovasculature due to decreased clearance at the blood‐brain barrier (BBB). However, the exact mechanism of Aβ clearance across this barrier has not been fully elucidated. The hCME...

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Udgivet i:J Neurosci Res
Main Authors: Biemans, Elisanne A.L.M., Jäkel, Lieke, de Waal, Robert M.W., Kuiperij, H. Bea, Verbeek, Marcel M.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484315/
https://ncbi.nlm.nih.gov/pubmed/27726164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.23964
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