CB(1) Allosteric Modulator Org27569 Is an Antagonist/Inverse Agonist of ERK1/2 Signaling

Introduction: Allosteric modulation of cannabinoid type-1 receptors (CB(1)) is a novel means through which signaling bias may be exerted. Org27569 remains the most-characterized CB(1) allosteric modulator, yet there are conflicting reports regarding its effects on extracellular signal-regulated kina...

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發表在:Cannabis Cannabinoid Res
Main Authors: Gamage, Thomas F., Anderson, Johnathon C., Abood, Mary E.
格式: Artigo
語言:Inglês
出版: Mary Ann Liebert, Inc., publishers 2016
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484173/
https://ncbi.nlm.nih.gov/pubmed/28660254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/can.2016.0028
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