In-vivo pharmacological evaluation of the CB(1)-receptor allosteric modulator Org-27569

Several allosteric modulators (AMs) of the CB(1) receptor have been characterized in vitro, including Org27569, which enhances CB(1)-specific binding of [(3)H]CP55,940, but behaves as an insurmountable CB(1)-receptor antagonist in several biochemical assays. Although a growing body of research has i...

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Autori principali: Gamage, Thomas F., Ignatowska-Jankowska, Bogna M., Wiley, Jenny L., Abdelrahman, Mostafa, Trembleau, Laurent, Greig, Iain R., Thakur, Ganesh A., Tichkule, Ritesh, Poklis, Justin, Ross, Ruth A., Pertwee, Roger G., Lichtman, Aron H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042670/
https://ncbi.nlm.nih.gov/pubmed/24603340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FBP.0000000000000027
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