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Total Synthesis of Brevenal

This manuscript describes the total synthesis of the marine ladder toxin brevenal utilizing a convergent synthetic strategy. Critical to the success of this work was the use of olefinic-ester cyclization reactions and the utilization of glycal epoxides as precursors to C–C and C–H bonds.

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Main Authors: Zhang, Yuan, Rohanna, John, Zhou, Jie, Iyer, Karthik, Rainier, Jon D.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484051/
https://ncbi.nlm.nih.gov/pubmed/21322562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja200089f
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