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HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome
HIV-1 replication can be efficiently inhibited by intracellular expression of an siRNA targeting the viral RNA. However, HIV-1 escape variants emerged after prolonged culturing. These RNAi-resistant viruses contain nucleotide substitutions or deletions in or near the targeted sequence. We observed a...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC548362/ https://ncbi.nlm.nih.gov/pubmed/15687388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki220 |
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