Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

T helper-17 (Th17) cells are associated with inflammatory disorders and cancer. We report that environmental conditions resulting in cellular stress, such as low oxygen, glucose, and isotonic stress, particularly enhance the generation of Th17 cells. Pharmacological inhibition of cell stress reduces...

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Publicado en:Cell Rep
Autores principales: Brucklacher-Waldert, Verena, Ferreira, Cristina, Stebegg, Marisa, Fesneau, Olivier, Innocentin, Silvia, Marie, Julien C., Veldhoen, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5483510/
https://ncbi.nlm.nih.gov/pubmed/28614720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.05.052
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