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Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

T helper-17 (Th17) cells are associated with inflammatory disorders and cancer. We report that environmental conditions resulting in cellular stress, such as low oxygen, glucose, and isotonic stress, particularly enhance the generation of Th17 cells. Pharmacological inhibition of cell stress reduces...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Brucklacher-Waldert, Verena, Ferreira, Cristina, Stebegg, Marisa, Fesneau, Olivier, Innocentin, Silvia, Marie, Julien C., Veldhoen, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5483510/
https://ncbi.nlm.nih.gov/pubmed/28614720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.05.052
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