MPA Modulates Tight Junctions' Permeability via Midkine/PI3K Pathway in Caco-2 Cells: A Possible Mechanism of Leak-Flux Diarrhea in Organ Transplanted Patients

Mycophenolic acid (MPA) is prescribed to prevent allograft rejection in organ transplanted patients. However, its use is sporadically linked to leak flux diarrhea and other gastrointestinal (GI) disturbances in around 75% of patients through yet unknown mechanisms. Recently, we identified Midkine as...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Khan, Niamat, Binder, Lutz, Pantakani, D. V. Krishna, Asif, Abdul R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5483464/
https://ncbi.nlm.nih.gov/pubmed/28694783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00438
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