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Evolution of the vertebrate insulin receptor substrate (Irs) gene family

BACKGROUND: Insulin receptor substrate (Irs) proteins are essential for insulin signaling as they allow downstream effectors to dock with, and be activated by, the insulin receptor. A family of four Irs proteins have been identified in mice, however the gene for one of these, IRS3, has been pseudoge...

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Detalhes bibliográficos
Publicado no:BMC Evol Biol
Main Authors: Al-Salam, Ahmad, Irwin, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482937/
https://ncbi.nlm.nih.gov/pubmed/28645244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12862-017-0994-z
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