Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice

The present study was conducted to determine if TRPC6 regulates glomerular filtration rate (GFR) and the contractile function of glomerular mesangial cells (MCs). GFR was assessed in conscious TRPC6 wild type and knockout mice, and in anesthetized rats with and without in vivo knockdown of TRPC6 in...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Li, Weizu, Ding, Yanfeng, Smedley, Crystal, Wang, Yanxia, Chaudhari, Sarika, Birnbaumer, Lutz, Ma, Rong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482875/
https://ncbi.nlm.nih.gov/pubmed/28646178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04067-z
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