Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes

The present study was performed to investigate the underlying mechanism, particularly the roles of reactive oxygen species (ROS) and protein kinase C (PKC), in the diabetes-induced canonical transient receptor potential 6 (TRPC6) downregulation. We found that high glucose (HG) significantly reduced...

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Main Authors: Graham, Sarabeth, Gorin, Yves, Abboud, Hanna E., Ding, Min, Lee, Duck Yoon, Shi, Honglian, Ding, Yanfeng, Ma, Rong
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2011
Ábhair:
Membrane Transporters, Ion Channels and Pumps
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154551/
https://ncbi.nlm.nih.gov/pubmed/21525431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00014.2011
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