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Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes

The present study was performed to investigate the underlying mechanism, particularly the roles of reactive oxygen species (ROS) and protein kinase C (PKC), in the diabetes-induced canonical transient receptor potential 6 (TRPC6) downregulation. We found that high glucose (HG) significantly reduced...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Graham, Sarabeth, Gorin, Yves, Abboud, Hanna E., Ding, Min, Lee, Duck Yoon, Shi, Honglian, Ding, Yanfeng, Ma, Rong
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	American Physiological Society 2011
الموضوعات:	Membrane Transporters, Ion Channels and Pumps
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3154551/ https://ncbi.nlm.nih.gov/pubmed/21525431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00014.2011
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Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes

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