Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes

The present study was performed to investigate the underlying mechanism, particularly the roles of reactive oxygen species (ROS) and protein kinase C (PKC), in the diabetes-induced canonical transient receptor potential 6 (TRPC6) downregulation. We found that high glucose (HG) significantly reduced...

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Detalhes bibliográficos
Main Authors: Graham, Sarabeth, Gorin, Yves, Abboud, Hanna E., Ding, Min, Lee, Duck Yoon, Shi, Honglian, Ding, Yanfeng, Ma, Rong
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Membrane Transporters, Ion Channels and Pumps
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154551/
https://ncbi.nlm.nih.gov/pubmed/21525431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00014.2011
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