Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906

Growth factor signaling via insulin receptor (IR) and IGF-1 receptor (IGF1R) plays several important roles in the pathogenesis of metabolic syndrome and diabetes. OSI-906 (linsitinib), an anti-tumor drug, is an orally bioavailable dual inhibitor of IR and IGF1R. To investigate the recovery from meta...

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Udgivet i:Sci Rep
Main Authors: Tajima, Kazuki, Shirakawa, Jun, Togashi, Yu, Yamazaki, Shunsuke, Okuyama, Tomoko, Kyohara, Mayu, Konishi, Hiromi, Terauchi, Yasuo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482874/
https://ncbi.nlm.nih.gov/pubmed/28646158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04304-5
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