Imaging of pH in vivo using hyperpolarized (13)C-labelled zymonic acid

Natural pH regulatory mechanisms can be overruled during several pathologies such as cancer, inflammation and ischaemia, leading to local pH changes in the human body. Here we demonstrate that (13)C-labelled zymonic acid (ZA) can be used as hyperpolarized magnetic resonance pH imaging sensor. ZA is...

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Udgivet i:Nat Commun
Main Authors: Düwel, Stephan, Hundshammer, Christian, Gersch, Malte, Feuerecker, Benedikt, Steiger, Katja, Buck, Achim, Walch, Axel, Haase, Axel, Glaser, Steffen J., Schwaiger, Markus, Schilling, Franz
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482723/
https://ncbi.nlm.nih.gov/pubmed/28492229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15126
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