Imaging of pH in vivo using hyperpolarized (13)C-labelled zymonic acid

Natural pH regulatory mechanisms can be overruled during several pathologies such as cancer, inflammation and ischaemia, leading to local pH changes in the human body. Here we demonstrate that (13)C-labelled zymonic acid (ZA) can be used as hyperpolarized magnetic resonance pH imaging sensor. ZA is...

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Foilsithe in:Nat Commun
Main Authors: Düwel, Stephan, Hundshammer, Christian, Gersch, Malte, Feuerecker, Benedikt, Steiger, Katja, Buck, Achim, Walch, Axel, Haase, Axel, Glaser, Steffen J., Schwaiger, Markus, Schilling, Franz
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482723/
https://ncbi.nlm.nih.gov/pubmed/28492229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15126
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