Generation of lung cancer cell lines harboring EGFR T790M mutation by CRISPR/Cas9-mediated genome editing

Tyrosine kinase inhibitors (TKIs) such as gefitinib and erlotinib are effective against lung adenocarcinomas harboring epidermal growth factor receptor (EGFR) mutations. However, cancer cells can develop resistance to these agents with prolonged exposure; in over 50% of cases, this is attributable t...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Park, Mi-Young, Jung, Min Hee, Eo, Eun Young, Kim, Seokjoong, Lee, Sang Hoon, Lee, Yeon Joo, Park, Jong Sun, Cho, Young Jae, Chung, Jin Haeng, Kim, Cheol Hyeon, Il Yoon, Ho, Lee, Jae Ho, Lee, Choon-Taek
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482658/
https://ncbi.nlm.nih.gov/pubmed/28422737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16752
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