Mechanism to develop inflammasome-independent and interferon-β-resistant EAE with neuronal damages

Inflammation induced by innate immunity influences the development of T cell-mediated autoimmunity in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). We found that strong activation of innate immunity induced NLRP3 inflammasome-independent and interfero...

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Pubblicato in:Nat Neurosci
Autori principali: Inoue, Makoto, Chen, Po-han, Siecinski, Stephen, Li, Qi-jing, Liu, Chunlei, Steinman, Lawrence, Gregory, Simon G., Benner, Eric, Shinohara, Mari L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482232/
https://ncbi.nlm.nih.gov/pubmed/27820602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4421
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