Exposure Matching for Extrapolation of Efficacy in Pediatric Drug Development

During drug development, matching adult systemic exposures of drugs is a common approach for dose selection in pediatric patients when efficacy is partially or fully extrapolated. This is a systematic review of approaches used for matching adult systemic exposures as the basis for dose selection in...

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Detalhes bibliográficos
Publicado no:J Clin Pharmacol
Main Authors: Mulugeta, Yeruk, Barrett, Jeffrey S., Nelson, Robert, Eshete, Abel Tilahun, Mushtaq, Alvina, Yao, Lynne, Glasgow, Nicole, Mulberg, Andrew E., Gonzalez, Daniel, Green, Dionna, Florian, Jeffry, Krudys, Kevin, Seo, Shirley, Kim, Insook, Chilukuri, Dakshina, Burckart, Gilbert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482171/
https://ncbi.nlm.nih.gov/pubmed/27040726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.744
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