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UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor–Induced NF-κB Signaling

Although over 40 type 1 diabetes (T1D) risk loci have been mapped in humans, the causative genes and variants for T1D are largely unknown. Here, we investigated a candidate gene in the 21q22.3 risk locus—UBASH3A, which is primarily expressed in T cells where it is thought to play a largely redundant...

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Publicat a:Diabetes
Autors principals: Ge, Yan, Paisie, Taylor K., Newman, Jeremy R.B., McIntyre, Lauren M., Concannon, Patrick
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482087/
https://ncbi.nlm.nih.gov/pubmed/28607106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1023
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