Metal Transporter Zip14 (Slc39a14) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity

Mutations in human ZIP14 have been linked to symptoms of the early onset of Parkinsonism and Dystonia. This phenotype is likely related to excess manganese accumulation in the CNS. The metal transporter ZIP14 (SLC39A14) is viewed primarily as a zinc transporter that is inducible via proinflammatory...

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Библиографические подробности
Опубликовано в: :J Neurosci
Главные авторы: Aydemir, Tolunay Beker, Kim, Min-Hyun, Kim, Jinhee, Colon-Perez, Luis M., Banan, Guita, Mareci, Thomas H., Febo, Marcelo, Cousins, Robert J.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2017
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Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481939/
https://ncbi.nlm.nih.gov/pubmed/28536273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0285-17.2017
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