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Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

BACKGROUND: Blood–brain barrier (BBB) breakdown and inflammation are critical events in ischemic stroke, contributing to aggravated brain damage. The BBB mainly consists of microvascular endothelial cells sealed by tight junctions to protect the brain from blood-borne substances. Thus, the maintenan...

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Bibliografische gegevens
Gepubliceerd in:J Neuroinflammation
Hoofdauteurs: Zhang, Haiying, Park, Joon Ha, Maharjan, Sony, Park, Jeong Ae, Choi, Kyu-Sung, Park, Hyojin, Jeong, Yoonjeong, Ahn, Ji Hyeon, Kim, In Hye, Lee, Jae-Chul, Cho, Jeong Hwi, Lee, In-Kyu, Lee, Choong Hyun, Hwang, In Koo, Kim, Young-Myeong, Suh, Young-Ger, Won, Moo-Ho, Kwon, Young-Guen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481915/
https://ncbi.nlm.nih.gov/pubmed/28645333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0897-3
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