Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

BACKGROUND: Blood–brain barrier (BBB) breakdown and inflammation are critical events in ischemic stroke, contributing to aggravated brain damage. The BBB mainly consists of microvascular endothelial cells sealed by tight junctions to protect the brain from blood-borne substances. Thus, the maintenan...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Zhang, Haiying, Park, Joon Ha, Maharjan, Sony, Park, Jeong Ae, Choi, Kyu-Sung, Park, Hyojin, Jeong, Yoonjeong, Ahn, Ji Hyeon, Kim, In Hye, Lee, Jae-Chul, Cho, Jeong Hwi, Lee, In-Kyu, Lee, Choong Hyun, Hwang, In Koo, Kim, Young-Myeong, Suh, Young-Ger, Won, Moo-Ho, Kwon, Young-Guen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481915/
https://ncbi.nlm.nih.gov/pubmed/28645333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0897-3
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