Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

Cancer chemoresistance and metastasis are tightly associated features. However, whether they share common molecular mechanisms and thus can be targeted with one common strategy remain unclear in non-small cell lung cancer (NSCLC). Here, we report that high levels of microRNA-128-3p (miR-128-3p) is k...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Cai, Junchao, Fang, Lishan, Huang, Yongbo, Li, Rong, Xu, Xiaonan, Hu, Zhihuang, Zhang, Le, Yang, Yi, Zhu, Xun, Zhang, Heng, Wu, Jueheng, Huang, Yan, Li, Jun, Zeng, Musheng, Song, Erwei, He, Yukai, Zhang, Li, Li, Mengfeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481840/
https://ncbi.nlm.nih.gov/pubmed/28627514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15870
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