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DOT1L safeguards cartilage homeostasis and protects against osteoarthritis
Osteoarthritis is the most prevalent and crippling joint disease, and lacks curative treatment, as the underlying molecular basis is unclear. Here, we show that DOT1L, an enzyme involved in histone methylation, is a master protector of cartilage health. Loss of DOT1L disrupts the molecular signature...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5481839/ https://ncbi.nlm.nih.gov/pubmed/28627522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15889 |
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