Suramin increases cartilage proteoglycan accumulation in vitro and protects against joint damage triggered by papain injection in mouse knees in vivo

OBJECTIVES: Suramin is an old drug used for the treatment of African sleeping sickness. We investigated therapeutic repositioning of suramin to protect against cartilage damage, as suramin may interact with tissue inhibitor of metalloproteinase-3 (TIMP3). METHODS: In vitro extracellular matrix (ECM)...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:RMD Open
Autori principali: Guns, Laura-An, Monteagudo, Silvia, Kvasnytsia, Maryna, Kerckhofs, Greet, Vandooren, Jennifer, Opdenakker, Ghislain, Lories, Rik J, Cailotto, Frederic
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2017
Soggetti:
Animal Models
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730881/
https://ncbi.nlm.nih.gov/pubmed/29299344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/rmdopen-2017-000604
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi