Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid

2,4-Dihydroxybutyric acid (DHB) is a molecule with considerable potential as a versatile chemical synthon. Notably, it may serve as a precursor for chemical synthesis of the methionine analogue 2-hydroxy-4-(methylthio)butyrate, thus, targeting a considerable market in animal nutrition. However, no n...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Walther, Thomas, Topham, Christopher M., Irague, Romain, Auriol, Clément, Baylac, Audrey, Cordier, Hélène, Dressaire, Clémentine, Lozano-Huguet, Luce, Tarrat, Nathalie, Martineau, Nelly, Stodel, Marion, Malbert, Yannick, Maestracci, Marc, Huet, Robert, André, Isabelle, Remaud-Siméon, Magali, François, Jean Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481828/
https://ncbi.nlm.nih.gov/pubmed/28631755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15828
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