Transforming growth factor β1 (TGFβ1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts

The appearance of myofibroblasts is generally thought to be the underlying cause of the fibrotic changes that underlie idiopathic pulmonary fibrosis. However, the cellular/molecular mechanisms that account for the fibroblast-myofibroblast differentiation/activation in idiopathic pulmonary fibrosis r...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Ghatak, Shibnath, Markwald, Roger R., Hascall, Vincent C., Dowling, William, Lottes, Robyn Grayson, Baatz, John E., Beeson, Gyada, Beeson, Craig C., Perrella, Mark A., Thannickal, Victor J., Misra, Suniti
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481558/
https://ncbi.nlm.nih.gov/pubmed/28389562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752451
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