Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease

BACKGROUND: The up-regulation of P-selectin in endothelial cells and platelets contributes to the cell–cell interactions that are involved in the pathogenesis of vaso-occlusion and sickle cell–related pain crises. The safety and efficacy of crizanlizumab, an antibody against the adhesion molecule P-...

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Bibliografski detalji
Izdano u:N Engl J Med
Glavni autori: Ataga, K.I., Kutlar, A., Kanter, J., Liles, D., Cancado, R., Friedrisch, J., Guthrie, T.H., Knight-Madden, J., Alvarez, O.A., Gordeuk, V.R., Gualandro, S., Colella, M.P., Smith, W.R., Rollins, S.A., Stocker, J.W., Rother, R.P.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481200/
https://ncbi.nlm.nih.gov/pubmed/27959701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1611770
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