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Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease
BACKGROUND: The up-regulation of P-selectin in endothelial cells and platelets contributes to the cell–cell interactions that are involved in the pathogenesis of vaso-occlusion and sickle cell–related pain crises. The safety and efficacy of crizanlizumab, an antibody against the adhesion molecule P-...
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Publicado no: | N Engl J Med |
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Main Authors: | , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5481200/ https://ncbi.nlm.nih.gov/pubmed/27959701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1611770 |
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