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Palladium-Catalyzed Pyrazole-Directed sp(3) C—H Bond Arylation for the Synthesis of β-Phenethylamines

We have developed a method for palladium-catalyzed, pyrazole-directed sp(3) C—H bond arylation by aryl iodides. The reaction employs a Pd(OAc)(2) catalyst at 5–10 mol% loading and silver(I) oxide as a halide-removal agent, and it proceeds in acetic acid or acetic acid/hexafluoroisopropanol solvent....

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Bibliografiska uppgifter
I publikationen:Angew Chem Int Ed Engl
Huvudupphovsmän: Gulia, Nurbey, Daugulis, Olafs
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5480374/
https://ncbi.nlm.nih.gov/pubmed/28233918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201611407
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