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In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity
Acquisition of α2-6 sialoside receptor specificity by α2-3 specific highly-pathogenic avian influenza viruses (H5N1) is thought to be a prerequisite for efficient transmission in humans. By in vitro selection for binding α2-6 sialosides, we identified four variant viruses with amino acid substitutio...
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| Izdano u: | Virology |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5480292/ https://ncbi.nlm.nih.gov/pubmed/22056389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2011.10.006 |
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