Eliminating acetate formation improves citramalate production by metabolically engineered Escherichia coli

BACKGROUND: Citramalate, a chemical precursor to the industrially important methacrylic acid (MAA), can be synthesized using Escherichia coli overexpressing citramalate synthase (cimA gene). Deletion of gltA encoding citrate synthase and leuC encoding 3-isopropylmalate dehydratase were critical to a...

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Dades bibliogràfiques
Publicat a:Microb Cell Fact
Autors principals: Parimi, Naga Sirisha, Durie, Ian A., Wu, Xianghao, Niyas, Afaq M. M., Eiteman, Mark A.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5480221/
https://ncbi.nlm.nih.gov/pubmed/28637476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-017-0729-2
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