Epigenome-wide Analysis Links SMAD3 Methylation at Birth to Asthma in Children of Asthmatic Mothers

BACKGROUND: The timing and mechanisms of asthma inception remain imprecisely defined. Although epigenetic mechanisms likely contribute to asthma pathogenesis, little is known about their role in asthma inception. OBJECTIVE: To assess whether the trajectory to asthma begins already at birth and epige...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: DeVries, Avery, Wlasiuk, Gabriela, Miller, Susan J., Bosco, Anthony, Stern, Debra A., Lohman, I. Carla, Rothers, Janet, Jones, Anya C., Nicodemus-Johnson, Jessie, Vasquez, Monica M., Curtin, John A., Simpson, Angela, Custovic, Adnan, Jackson, Daniel J., Gern, James E., Lemanske, Robert F., Guerra, Stefano, Wright, Anne L., Ober, Carole, Halonen, Marilyn, Vercelli, Donata
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479765/
https://ncbi.nlm.nih.gov/pubmed/28011059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.10.041
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