Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

Aberrant activation of the SRC family kinase hematopoietic cell kinase (HCK) triggers hematological malignancies as a tumor cell-intrinsic oncogene. Here we find that high HCK levels correlate with reduced survival of colorectal cancer patients. Likewise, increased Hck activity in mice promotes the...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Cell
Main Authors: Poh, Ashleigh R., Love, Christopher G., Masson, Frederick, Preaudet, Adele, Tsui, Cary, Whitehead, Lachlan, Monard, Simon, Khakham, Yelena, Burstroem, Lotta, Lessene, Guillaume, Sieber, Oliver, Lowell, Clifford, Putoczki, Tracy L., O’Donoghue, Robert J.J., Ernst, Matthias
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479329/
https://ncbi.nlm.nih.gov/pubmed/28399411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.03.006
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki