Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

Aberrant activation of the SRC family kinase hematopoietic cell kinase (HCK) triggers hematological malignancies as a tumor cell-intrinsic oncogene. Here we find that high HCK levels correlate with reduced survival of colorectal cancer patients. Likewise, increased Hck activity in mice promotes the...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Poh, Ashleigh R., Love, Christopher G., Masson, Frederick, Preaudet, Adele, Tsui, Cary, Whitehead, Lachlan, Monard, Simon, Khakham, Yelena, Burstroem, Lotta, Lessene, Guillaume, Sieber, Oliver, Lowell, Clifford, Putoczki, Tracy L., O’Donoghue, Robert J.J., Ernst, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479329/
https://ncbi.nlm.nih.gov/pubmed/28399411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.03.006
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