Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo

The present work proposes a unique de-PEGylation strategy for controllable delivery of small interfering RNA (siRNA) using a robust lipid-polymer hybrid nanoparticle (NP) platform. The self-assembled hybrid NPs are composed of a lipid-poly(ethylene glycol) (lipid-PEG) shell and a polymer/cationic li...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Zhu, Xi, Tao, Wei, Liu, Danny, Wu, Jun, Guo, Zilei, Ji, Xiaoyuan, Bharwani, Zameer, Zhao, Lili, Zhao, Xiaoping, Farokhzad, Omid C., Shi, Jinjun
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479285/
https://ncbi.nlm.nih.gov/pubmed/28638484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.18136
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