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Inositol 1,4,5-trisphosphate receptor/GAPDH complex augments Ca(2+) release via locally derived NADH

NADH regulates the release of calcium from the endoplasmic reticulum by modulation of inositol 1,4,5-trisphosphate receptors (IP(3)R), accounting for the augmented calcium release of hypoxic cells. We report selective binding of IP(3)R to GAPDH, whose activity leads to the local generation of NADH t...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Patterson, Randen L., van Rossum, Damian B., Kaplin, Adam I., Barrow, Roxanne K., Snyder, Solomon H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC547892/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15677321/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0409657102
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