Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling

β-arrestins bind to G protein-coupled receptor kinase (GRK)-phosphorylated seven transmembrane receptors, desensitizing their activation of G proteins, while concurrently mediating receptor endocytosis, and some aspects of receptor signaling. We have used RNA interference to assess the roles of the...

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Detalles Bibliográficos
Autores principales: Kim, Jihee, Ahn, Seungkirl, Ren, Xiu-Rong, Whalen, Erin J., Reiter, Eric, Wei, Huijun, Lefkowitz, Robert J.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2005
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC547874/
https://ncbi.nlm.nih.gov/pubmed/15671181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409532102
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