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Enhanced antiviral and antifibrotic effects of short hairpin RNAs targeting HBV and TGF-β in HBV-persistent mice

The hepatitis B virus (HBV) causes acute and chronic liver infection, which may lead to liver cirrhosis and hepatocellular carcinoma. Current treatments including interferons and nucleotide analogs, have limited therapeutic effects, underscoring the need to identify effective therapeutic options to...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ye, Lei, Kan, Fangming, Yan, Tao, Cao, Jiaqi, Zhang, Leiliang, Wu, Zhijian, Li, Wuping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478661/
https://ncbi.nlm.nih.gov/pubmed/28634402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04170-1
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