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Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer
Epigenetic deregulation is of importance in tumorigenesis. In particular CpG islands (CGI), are frequently hypermethylated. Here, genome-wide DNA-methylation profiles of 480,000 CpGs in lung cancer cells were generated. It was observed that intra- and intergenic CGI exhibited higher methylation comp...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5478622/ https://ncbi.nlm.nih.gov/pubmed/28634396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04248-w |
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