Structural basis to stabilize the domain motion of BARD1-ARD BRCT by CstF50

BRCA1 associated ring domain protein 1(BARD1) is a tumor suppressor protein having a wide role in cellular processes like cell-cycle checkpoint, DNA damage repair and maintenance of genomic integrity. Germ-line mutation Gln 564 His discovered in linker region of BARD1 leads to loss of binding to Cle...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Choudhary, Rajan Kumar, Siddiqui, Mohd Quadir, Thapa, Pankaj S., Gadewal, Nikhil, Nachimuthu, Senthil Kumar, Varma, Ashok K.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478621/
https://ncbi.nlm.nih.gov/pubmed/28634376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03816-4
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