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Plasticity, dynamics, and inhibition of emerging tetracycline-resistance enzymes

While tetracyclines are an important class of antibiotics in agriculture and the clinic, their efficacy is threatened by increasing resistance. Resistance to tetracyclines can occur through efflux, ribosomal protection, or enzymatic inactivation. Surprisingly, tetracycline enzymatic inactivation has...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Park, Jooyoung, Gasparrini, Andrew J., Reck, Margaret R., Symister, Chanez T., Elliott, Jennifer L., Vogel, Joseph P., Wencewicz, Timothy A., Dantas, Gautam, Tolia, Niraj H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478473/
https://ncbi.nlm.nih.gov/pubmed/28481346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2376
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