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Enthalpy of helix–coil transition: Missing link in rationalizing the thermodynamics of helix-forming propensities of the amino acid residues

It is known that different amino acid residues have effects on the thermodynamic stability of an α-helix. The underlying mechanism for the thermodynamic helical propensity is not well understood. The major accepted hypothesis is the difference in the side-chain configurational entropy loss upon heli...

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Autori principali: Richardson, John M., Lopez, Maria M., Makhatadze, George I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC547846/
https://ncbi.nlm.nih.gov/pubmed/15671166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408004102
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