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Enthalpy of helix–coil transition: Missing link in rationalizing the thermodynamics of helix-forming propensities of the amino acid residues

It is known that different amino acid residues have effects on the thermodynamic stability of an α-helix. The underlying mechanism for the thermodynamic helical propensity is not well understood. The major accepted hypothesis is the difference in the side-chain configurational entropy loss upon heli...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Richardson, John M., Lopez, Maria M., Makhatadze, George I.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC547846/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15671166/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408004102
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