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Clinical development of fenretinide as an antineoplastic drug: Pharmacology perspectives

Fenretinide (4-HPR) is a synthetic retinoid that has cytotoxic activity against cancer cells. Despite substantial in vitro cytotoxicity, response rates in early clinical trials with 4-HPR have been less than anticipated, likely due to the low bioavailability of the initial oral capsule formulation....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Exp Biol Med (Maywood)
Prif Awduron: Cooper, Jason P, Reynolds, C Patrick, Cho, Hwangeui, Kang, Min H
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: SAGE Publications 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478002/
https://ncbi.nlm.nih.gov/pubmed/28429653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370217706952
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