Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus.

Regulation of tyrosine hydroxylase expression by antidepressant treatments was investigated in the locus coeruleus (LC), the major noradrenergic nucleus in brain. Rats were treated chronically with various antidepressants, and tyrosine hydroxylase levels were measured in the LC by immunoblot analysi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Nestler, E J, McMahon, A, Sabban, E L, Tallman, J F, Duman, R S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54779/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1977162/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.19.7522
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