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NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery

NK cells are a major component of the immune system, and alterations in their activity are correlated with various autoimmune diseases. In the present work, we observed an increased expression of the NKG2D ligand MICA in SLE patients’ kidneys but not healthy subjects. We also show glomerulus-specifi...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Spada, Roberto, Rojas, José M., Pérez-Yagüe, Sonia, Mulens, Vladimir, Cannata-Ortiz, Pablo, Bragado, Rafael, Barber, Domingo F.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477896/
https://ncbi.nlm.nih.gov/pubmed/25583577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.4A0714-326R
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