Human NK cells maintain licensing status and are subject to killer immunoglobulin-like receptor (KIR) and KIR-ligand inhibition following ex vivo expansion

Infusion of allogeneic NK cells is a potential immunotherapy for both hematopoietic malignancies and solid tumors. Interactions between killer immunoglobulin-like receptors (KIR) on human NK cells and KIR-ligands on tumor cells influence the magnitude of NK function. To obtain sufficient numbers of...

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Bibliografiske detaljer
Udgivet i:Cancer Immunol Immunother
Main Authors: Wang, Wei, Erbe, Amy K., Alderson, Kory A., Phillips, Emily, Gallenberger, Mikayla, Gan, Jacek, Campana, Dario, Hank, Jacquelyn A., Sondel, Paul M.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477646/
https://ncbi.nlm.nih.gov/pubmed/27392940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-016-1864-z
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