The albumin-exendin-4 recombinant protein E2HSA improves glycemic control and β-cell function in spontaneous diabetic KKAy mice

BACKGROUND: E2HSA is a genetic fusion protein that consists of two tandem exendin-4 molecules that are covalently bonded to recombinant human serum albumin via a peptide linker. Previous studies have demonstrated that E2HSA significantly decreased blood glucose levels, improved β-cell function and p...

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Publicado en:BMC Pharmacol Toxicol
Autores principales: Li, Caina, Hou, Shaocong, Liu, Shuainan, Huan, Yi, Sun, Sujuan, Liu, Quan, Shen, Zhufang
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477380/
https://ncbi.nlm.nih.gov/pubmed/28629388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-017-0143-8
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