The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

Microbial pattern molecules in the intestine play immunoregulatory roles via diverse pattern recognition receptors. However, the role of the cytosolic DNA sensor AIM2 in the maintenance of intestinal homeostasis is unknown. Here, we show that Aim2(−/−) mice are highly susceptible to dextran sodium s...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Hu, Shuiqing, Peng, Lan, Kwak, Youn-Tae, Tekippe, Erin McElvania, Pasare, Chandrashekhar, Malter, James S., Hooper, Lora V., Zaki, Md. Hasan
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477202/
https://ncbi.nlm.nih.gov/pubmed/26655906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.040
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