The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

Microbial pattern molecules in the intestine play immunoregulatory roles via diverse pattern recognition receptors. However, the role of the cytosolic DNA sensor AIM2 in the maintenance of intestinal homeostasis is unknown. Here, we show that Aim2(−/−) mice are highly susceptible to dextran sodium s...

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Vydáno v:Cell Rep
Hlavní autoři: Hu, Shuiqing, Peng, Lan, Kwak, Youn-Tae, Tekippe, Erin McElvania, Pasare, Chandrashekhar, Malter, James S., Hooper, Lora V., Zaki, Md. Hasan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477202/
https://ncbi.nlm.nih.gov/pubmed/26655906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.040
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