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Nickel-Catalyzed Reduction of Secondary and Tertiary Amides

The nickel-catalyzed reduction of secondary and tertiary amides to give amine products is reported. The transformation is tolerant of extensive variation with respect to the amide substrate, proceeds in the presence of esters and epimerizable stereocenters, and can be used to achieve the reduction o...

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Bibliographic Details
Published in:Org Lett
Main Authors: Simmons, Bryan J., Hoffmann, Marie, Hwang, Jaeyeon, Jackl, Moritz K., Garg, Neil K.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476940/
https://ncbi.nlm.nih.gov/pubmed/28339212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b00683
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