Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections

Rationale: Previous work indicates that ivacaftor improves cystic fibrosis transmembrane conductance regulator (CFTR) activity and lung function in people with cystic fibrosis and G551D-CFTR mutations but does not reduce density of bacteria or markers of inflammation in the airway. These findings ra...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Hisert, Katherine B., Heltshe, Sonya L., Pope, Christopher, Jorth, Peter, Wu, Xia, Edwards, Rachael M., Radey, Matthew, Accurso, Frank J., Wolter, Daniel J., Cooke, Gordon, Adam, Ryan J., Carter, Suzanne, Grogan, Brenda, Launspach, Janice L., Donnelly, Seamas C., Gallagher, Charles G., Bruce, James E., Stoltz, David A., Welsh, Michael J., Hoffman, Lucas R., McKone, Edward F., Singh, Pradeep K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476912/
https://ncbi.nlm.nih.gov/pubmed/28222269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201609-1954OC
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