Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections

Rationale: Previous work indicates that ivacaftor improves cystic fibrosis transmembrane conductance regulator (CFTR) activity and lung function in people with cystic fibrosis and G551D-CFTR mutations but does not reduce density of bacteria or markers of inflammation in the airway. These findings ra...

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Publicat a:Am J Respir Crit Care Med
Autors principals: Hisert, Katherine B., Heltshe, Sonya L., Pope, Christopher, Jorth, Peter, Wu, Xia, Edwards, Rachael M., Radey, Matthew, Accurso, Frank J., Wolter, Daniel J., Cooke, Gordon, Adam, Ryan J., Carter, Suzanne, Grogan, Brenda, Launspach, Janice L., Donnelly, Seamas C., Gallagher, Charles G., Bruce, James E., Stoltz, David A., Welsh, Michael J., Hoffman, Lucas R., McKone, Edward F., Singh, Pradeep K.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2017
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476912/
https://ncbi.nlm.nih.gov/pubmed/28222269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201609-1954OC
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