Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections

Rationale: Previous work indicates that ivacaftor improves cystic fibrosis transmembrane conductance regulator (CFTR) activity and lung function in people with cystic fibrosis and G551D-CFTR mutations but does not reduce density of bacteria or markers of inflammation in the airway. These findings ra...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Am J Respir Crit Care Med
Κύριοι συγγραφείς: Hisert, Katherine B., Heltshe, Sonya L., Pope, Christopher, Jorth, Peter, Wu, Xia, Edwards, Rachael M., Radey, Matthew, Accurso, Frank J., Wolter, Daniel J., Cooke, Gordon, Adam, Ryan J., Carter, Suzanne, Grogan, Brenda, Launspach, Janice L., Donnelly, Seamas C., Gallagher, Charles G., Bruce, James E., Stoltz, David A., Welsh, Michael J., Hoffman, Lucas R., McKone, Edward F., Singh, Pradeep K.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Thoracic Society 2017
Θέματα:
Original Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476912/
https://ncbi.nlm.nih.gov/pubmed/28222269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201609-1954OC
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